I can’t say yes or no as I don’t use skewers but rather under track uncoupling magnets or the Rix Products uncoupling tool. A pair of magnets on a handle that you simply put over the two couples and move sort of twist it and they uncouple, really slick little tool.
As far as using #58 I started to switched to them as I read they were more prototypical as they couple the cars closer together then #5’s. So far I am happy with them and have no complaints. I typically run nothing large then a 50’ freight car mainly 40’ as it’s more to the era I model.
You got me curious so I just went down and checked. I was able to easily uncouple cars when both are equipped with #58 couplers. I used a craft stick cut at about a 20 degree angle on the end. I tried on several different pairs of cars and it worked well. The key, as always, when manually uncoupling knuckle style couplers is to make sure there is a little slack between the two cars.
Just my (very limited) experience. Your mileage may vary.