The fact that the lights go off after a few seconds is exactly what I saw. Remember, the PC, Board and JMRI all have to agree on the baud rate.
You might have been worried by the different board jumpers mentioned.
Looking at page 3 or the instructions, it does mention the version of Powercab you are using. Since mine reports as 1.65 I used the jumpers On, Off, On, On. That requires the 19200 baud rate setup in Windows and JMRI.
Jumper 1 is the baud rate, 9600 or 19200.
https://www.dropbox.com/s/fnltxffuhvekg8z/Uart.PNG?dl=0
If your Powercab reports as 1.28c, then use the jumper settings from the chart for 1.28c.
One of the annoying parts of the instructions is being incomplete especially for jumper 1. I am sure you have seen these articles, but to be sure:
https://ncedcc.zendesk.com/hc/en-us/articles/115001995503-USB-Interface-Read-Me-First
There are a couple of links on the side for other articles.
This link is the updated USB manual. I does mention jumper 1:
https://www.dccconcepts.com/wp-content/uploads/2016/02/NCE-USB-Manual-v7.0.pdf
Oh, and the Universal driver is the only one that specifically supports Windows10 so use that.
You are not alone in this. Many many people have had problems and that includes me. I’ve had decades of professional computer and electronics experience but DCC manufacturers seem to delight in making manuals that defy normal intelligent people. (I am looking at you Digitrax and ESU.) The annoying thing is that you are possibly making the same wrong assumption each time. That leads to madness and frustation.