Yes, a somewhat different geometry than with the proportions of the standard gauge car vs 4’ 8.5" gauge. More of the carbody ends up as overhang. Typically, this is aggravated by marginal bolster design on many HOn3 models. Often, just a thick plank of wood comprises the bolster. Blackstone does a really good job on theirs, but that’s the exception. The kingpin is usually a screw and its fit is often a bit loose and sloppy, depending on the truck, so it further contributes to less than optimal operation. Some of this can be fixed. If you order a pair of Blackstone passenger trucks, they come with one of their formed bolsters IIRC. Not always a solution for an already built model, but a little effort to improve this helps things.
More and more manufacturers are bringing out cars that are close to the recommenced standards, Accurail, Walthers, and Atlas and Athearn lately. Adjusting the weight on older blue box cars and MDC from the last century (I know I’m dating myself) makes the train perform better. The Megow cars however are almost impossible to reweigh. All I need now is to convert two American Flyer HO AC NYC Hudsons to DCC.