I reviewed a copy of the October 1878 issue of the Official Guide and I was able to come up with two possible routing scenarios for a Jacksonville-Little Rock trip:
VIA MONTGOMERY - southbound
Memphis and Little Rock Railway
Leave Little Rock, AR 3: 25 PM
Arrive Memphis, TN 11:40 PM
Memphis and Charleston RR
Leave Memphis, TN 12:10AM
Arrive Decatur, AL 10:10AM
Louisville and Great Southern Line
Leave Decatur, AL 12:45PM
Arrive Montgomery, AL 7:30 PM
Montgomery & Eufaula RR
Leave Montgomery, AL 10:30PM
Arrive Eufaula, AL 5:25 AM
South-west RR (Central of Georgia)
Leave Eufaula, AL 8:30 AM
Arrive Smithville, GA 12:00 N
Leave Smithville, GA 12:40 PM
Arrive Albany, GA 2:08 PM
Atlantic & Gulf
Leave Albany, GA 2:30PM
Arrive Dupont, GA 9:55 PM
Leave Dupont , GA10:05 PM
Arrive Live Oak, FL 12:50 AM
Jacksonville, Peninsula and Mobile
Leave Live Oak. FL 12:50 AM
Arrive Lake City, FL 2:15 AM
Florida Central
Leave Lake City, FL 2:35 AM
Arrive Jacksonville, FL 6:35 AM
VIA MONTGOMERY - northbound
Florida Central
Leave Jacksonville, FL 5:00 PM
Arrive Lake City, FL 8:55 PM
Jacksonville, Peninsula and Mobile
Leave Lake City, FL 9:15 PM
Arrive Live Oak, FL 10:30 PM
Atlantic & Gulf
Leave Live Oak, FL 10:40 PM
Arrive Dupont, GA 1:40 AM
Leave Dupont, GA 2:15 AM
Arrive Albany, GA 9:50 AM
South-west RR (Central of Georgia)
Leave Albany, GA 10:10 AM
Arrive Smithville, GA 11:45 AM
Leave Smithville, GA 12:45 PM
Arrive Eufaula, AL 3:36 PM
Montgomery & Eufaula RR
Leave Eufaula, AL 9:55 PM
Arrive Montgomery, AL 5:30 AM
Louisville and Great Southern Line
Leave Montgomery, AL 5:40AM
Arrive Decatur,